Drugs & Vitamins

Active Ingredients: Penicillamine
Other Names: Depen Tablets, Depen Titratable Tablets
Rx Status: Available by prescription only
Generic Available: No
Product Images & Descriptions:

What is/are Depen? (Back to top)
PENICILLAMINE binds with heavy metals and cystine in the body. It is used to treat Wilson's disease and cystinuria. It is also used to treat rheumatoid arthritis. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine? (Back to top)
They need to know if you have any of these conditions:

• anemia or other blood disorders
• kidney disease
• myasthenia gravis
• an unusual or allergic reaction to penicillamine, penicillin, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine? (Back to top)
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 1 hour before or 2 hours after food. Do not take with food. Take this medicine at least one hour apart from milk or other medicines. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not skip doses or stop your medicine even if you feel better. Skipping doses for even a few days may cause you to have allergic reactions after restarting this medicine. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose? (Back to top)
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine? (Back to top)
Do not take this medicine with any of the following:

• medicines for malaria

• certain antacids that contain aluminum, magnesium
• chemotherapy
• gold compounds used for arthritis
• iron tablets
• multi-vitamins with metals, minerals or iron
• oxyphenbutazone, phenylbutazone

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine? (Back to top)
Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• black, tarry stools
• breathing problems
• changes in vision
• dark urine
• dizzy, lightheaded
• fever, chills, sore throat
• joint pain
• mouth sores
• numbness, tingling pain
• redness, blistering, peeling or loosening of the skin, including inside the mouth
• swollen or painful glands
• trouble passing urine or change in the amount of urine
• unusual bleeding or bruising
• unusually weak or tired

• anxiety, irritation
• changes in taste
• diarrhea
• loss of appetite
• nausea, vomiting
• stomach pain
• wrinkled or loose skin

This list may not describe all possible side effects.

What should I watch for while using this medicine? (Back to top)
Visit your doctor or health care professional for regular check ups. It may take 2 to 3 months to improve your symptoms. Tell your doctor if your symptoms do not improve or if you get any new symptoms. You will need to have important blood work done while on this medicine.

You may need to be on a special diet while taking this medicine. Check with your doctor. Ask if you need to take extra vitamin B6 or a multi-vitamin while taking this medicine.

If you are taking this medicine to prevent kidney stones you need to drink plenty of water. Drink at least 2 full glasses of water at bedtime and 2 more full glasses of water during the night.

If you are going to have surgery, tell your doctor or health care professional that you are taking this medicine.

Where should I keep this medicine? (Back to top)
Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep the medicine container closed tightly. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Last Updated:December 12, 2006

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